astrazeneca vaccine ingredients pdf

LqIai8O=,*EM~|>0: NiV|+'#M(FYQc`uic+)Gy1Q(:'4~0:,9Dbdf&. 0000093171 00000 n United Kingdom, MedImmune Pharma B.V., Nijmegen 3. Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. 0000003743 00000 n }wfydUj_mr\]]s=']O_Od>MdD.PHTpo Such reactions may include a combination of any of the following symptoms: In clinical studies with the vaccine, fewer side effects were reported after the second dose and those that were reported were milder in nature when compared to after the first dose. Possible side effects 5. When these blood clots do occur, they may be in unusual or atypical locations (e.g. 0000100043 00000 n We comply with the HONcode standard for trustworthy health information. How to store COVID-19 Vaccine AstraZeneca 6. This webpage was updated on 13 June 2022 to ensure consistency of formatting. Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. 0000054470 00000 n However, a mild fever or infection, like a cold, are not reasons to delay vaccination; If you have ever had a condition known as heparin-induced thrombocytopenia and thrombosis (HITT or HIT type 2), or a blood clot in the sinus veins in the brain; If you have a problem with bleeding or bruising, or if you are taking a blood thinning medicine (anticoagulant); If your immune system does not work properly (immunodeficiency) or you are taking medicines that weaken the immune system (such as high-dose corticosteroids, immunosuppressants or cancer medicines). 346 0 obj <> endobj x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! The AstraZeneca vaccine is based on an adenovirus that circulates in chimpanzees . 0000085176 00000 n 0000006680 00000 n Vaccine ingredients; Nucleic acid and viral vector vaccines explained . 0000007733 00000 n Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. 0000011249 00000 n This explainer is more than 90 days old. 0000107188 00000 n To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. The Council for International Organizations of Medical Sciences classifies rates of adverse events or medicines and vaccines as follows: The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about Participants will receive 2 doses of AZD1222; the first dose will be administered on Day 1 and the second dose on Day 29. As new data become available, WHO will update recommendations accordingly. trailer $x >HdA@; During use it can be stored from 2C to 25C. trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream It is not yet known how long you will be protected for. 0000081617 00000 n . 0000004761 00000 n This information was provided by the drug's manufacturer when this drug product was approved for sale in Canada. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. By reporting side effects you can help provide more information on the safety of this vaccine. Messenger RNA (mRNA) Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. brain, liver, bowel, spleen). Some people have reported a sudden feeling of cold with shivering/shaking accompanied by a rise in temperature, possibly with sweating, headache (including migraine-like headaches), nausea, muscle aches and feeling unwell, starting within a day of having the vaccine and usually lasting for a day or two. If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. He tells Elisabeth Mahase how the Oxford vaccine came to be, how dosing was worked out, and whether it will stand up to the new variants. In all participants, a T-cell response was induced, peaking by day 14, and maintained two months after injection. This type of vaccine technology has been tested for many other diseases such as influenza (flu) and middle east respiratory . The last nine ingredients on the list are called 'excipients.' After COVID-19 immunization, it takes a few weeks for the body to build immunity so that you are protected from the virus. Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety endstream The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. Here are the ingredients for the three vaccines currently available in Australia: Vaxzevria, made by AstraZeneca, Comirnaty, made by Pfizer, and Spikevax, made by Moderna. %%EOF syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). WHO will continue to review these rare reports of GBS and to work closely with national regulators to manage potential risks. endstream endobj 549 0 obj <. But individuals may choose to delay vaccination for 3 months following the infection. When autocomplete results are available use up and down arrows to review and enter to select. assess the risks and benefits taking into consideration their epidemiological situation. % Title: Redirect for COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients Author: CDC/NCIRD Subject: 56 0 obj Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. The second stage (Phase II) involves testing the vaccine on people who have similar characteristics (such as age and physical health) to the target population, or the group for which the vaccine is intended. &Va(f+0&+FIcDHoL To help pregnant women make this assessment, they should be provided with Guillain-Barr syndrome (GBS) has been reported very rarely following vaccination. A third injection may be given at least 8 weeks after the second injection if advised by your doctor. Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. (Centers for Disease Control and Prevention). %PDF-1.7 % Very low levels of blood platelets (immune thrombocytopenia), that can be associated with bleeding, have been reported very rarely, usually within the first four weeks following vaccination with COVID-19 Vaccine AstraZeneca. The AstraZeneca vaccine does contain polysorbate. 4 to 12 weeks. impact. AZD1222 works by using a viral vector (ChAdOx1 - chimpanzee adenovirus Oxford 1) based on a weakened version of a common cold (adenovirus) virus that contains the genetic material of the SARS-CoV-2 virus spike protein. 0000003223 00000 n /Root 55 0 R If you get any side effects, talk to your doctor, pharmacist or nurse. JZD| 0000010323 00000 n The goal of this stage is to identify the most effective dosages and schedule for Phase III trials. 0000107040 00000 n Last updated by Judith Stewart, BPharm on Feb 15, 2021.. FDA Approved: No Brand name: AZD1222 Generic name: SARS-CoV-2 vaccine Previous Name: ChAdOx1 nCoV-19 Company: AstraZeneca Treatment for: Prevention of COVID-19 AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. Published: 2021-05-07. Wait until any effects of the vaccine have worn off before you drive or use machines. This includes any possible side effects not listed in this leaflet. 0000019840 00000 n EVIDENCE ASSESSMENT: BBIBP COVID-19 vaccine (BBIBP-CorV) Key evidence to inform policy recommendations on the use of BBIBP-CorV The SAGE Working Group specifically considered the following questions: 1. It has been adjusted to work as a delivery system for the vaccine. If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before you receive this vaccine. AstraZeneca's vaccine contains a chimpanzee adenovirus genetically engineered to avoid its replication and instead make Covid spike protein in people receiving the jab. Treatment for: Prevention of COVID-19. 0000006590 00000 n The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. 967 0 obj <>stream One dose (0.5 ml) contains: Adenoviruses are a common group of viruses that cause different types of sicknesses like bronchitis. hbbd``b` $HpXAv DL) 0000088968 00000 n What COVID-19 Vaccine AstraZeneca is and what it is used for, What you need to know before you are given COVID-19 Vaccine AstraZeneca, How COVID-19 Vaccine AstraZeneca is given, How to store COVID-19 Vaccine AstraZeneca, Contents of the pack and other information, Check benefits and financial support you can get, Find out about the Energy Bills Support Scheme, Regulatory approval of COVID-19 Vaccine AstraZeneca, Package leaflet: Information for the recipient, nationalarchives.gov.uk/doc/open-government-licence/version/3. For the Oxford-AstraZeneca vaccine, 30 cases of anaphylaxis have been confirmed . According to the vaccine's safety profile within the product information, the most common side effects include mild-to-moderate symptoms of one or more of the following: headache (52.6%) fatigue . COVID-19 Vaccine (ChAdOx1 S [recombinant]). Efficacy. 0000005016 00000 n %%EOF 0 COVID-19 Vaccine AstraZeneca is given to adults aged 18 years and older. Vaxzevria is a vaccine for preventing coronavirus disease 2019 (COVID-19) in people aged 18 years and older. Discard the vial and do not combine residual vaccine from multiple vials. If you are allergic to any of the active substances or any of the other ingredients listed in section 6. Produced in genetically modified human embryonic kidney (HEK) 293 cells. 0000000016 00000 n COVID-19 Vaccine AstraZeneca is not recommended for children aged below 18 years. 0000098136 00000 n This means that a COVID-19 vaccine cannot make you sick with COVID-19. The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. COVID-19 Vaccine AstraZeneca contains genetically modified organisms (GMOs). Your doctor, pharmacist or nurse is responsible for storing this vaccine and disposing of any unused product correctly. Page last updated Thursday, May 26, 2022 0000009792 00000 n 0000132021 00000 n /ID [<46442D36362D36432D33412D43412D36>] s/s's?3on1;XX(@?<=f@(tv4;r% ~IX 841 0 obj <>/Filter/FlateDecode/ID[<361FB7422BB7104D9CF07822BCE868F6>]/Index[818 53]/Info 817 0 R/Length 108/Prev 89098/Root 819 0 R/Size 871/Type/XRef/W[1 2 1]>>stream 346 65 Dont worry we wont send you spam or share your email address with anyone. [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. The shot gives the body instructions to create the spike protein from COVID-19 in its cells. SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. What COVID-19 Vaccine AstraZeneca is and what it is used for COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID-19, caused by a virus called coronavirus (SARS-CoV-2). on AstraZeneca COVID-19 vaccine for reports of very rare side effects. If you get any side effects, talk to your doctor, pharmacist or nurse. 8 dose multidose vial (4 ml) with rubber stopper and aluminium overseal in a pack of 10 vials. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. endobj The majority of recipients were White (75.5%), 10.1% were Black and 3.5% were Asian; 55.8% were female and 44.2% male. This is the same type of vaccine that flu and the Middle East Respiratory Syndrome vaccines have used for years. These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration. 0000003094 00000 n The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. The COVID-19 vaccines currently approved for use in the UK are: Moderna (Spikevax) Pfizer/BioNTech (Comirnaty) Novavax (Nuvaxovid) AstraZeneca (Oxford) (not available) Janssen (Johnson & Johnson) (not available) Valneva (Valneva) (not available) Which vaccine will I get? 55 0 obj This type of vaccine development technology has been tested for many other diseases such as influenza (flu) and Middle East respiratory syndrome coronavirus (MERS-CoV). endstream endobj 75 0 obj <> stream O'`` r/ RV"Lj~=n%8w?C * Systemic reactions were common in the AZD1222 without paracetamol group, with 340 (70%) reporting fatigue and 31 (68%) reporting headache. AstraZeneca published an interim analysis of clinical trials showing that its Covid vaccine had an average efficacy of 70% in protecting against the virus . are no data yet for Omicron. CoronaVac is an inactivated vaccine. It is important that you return for your second injection of COVID-19 Vaccine AstraZeneca. 0000024916 00000 n 0000098956 00000 n ]0[ This included some severe cases with blood clots in different or unusual locations and excessive clotting or bleeding throughout the body. hb``g``oc`c` @1v=k}u F'SUNZ A very rare adverse event called Thrombosis with Thrombocytopenia Syndrome (TTS), involving unusual and severe blood clotting events associated with low platelet counts, has been reported after vaccination with this vaccine. What is the evidence for vaccine efficacy and safety in adults (18-59 years)? 18 June 2021. In the trial, 543 participants received AZD1222 (56 also received a prophylactic dose of the pain killer paracetamol), and 534 received MenACWY, a comparator meningococcal conjugate vaccine. If side effects such as pain and/or fever are troublesome, medicines containing paracetamol can be taken. 0000103790 00000 n An email has been sent to you to confirm your subscription. 0000056130 00000 n If you previously had Guillain-Barr syndrome (temporary loss of feeling and movement) or transverse myelitis (inflammation of the spinal cord) after being given COVID-19 Vaccine AstraZeneca. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. 0000055862 00000 n Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. Available for Android and iOS devices. Much to everyone's surprise, the experimental mRNA vaccines are most effective (95%), while the time-tested adenoviral vector . 0000007231 00000 n 0000099076 00000 n SAGE currently recommends its use according to the WHO Prioritization Roadmap, even if virus variants are present in a country. Dosage level (s) 5 1010 vp (nominal). Nijmegen, 6545CG SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks. {zzZ`ntK?D6r|D#T$* TGBKz. Consumer Information. This article has been translated from its original language. Each vial contains 10 doses of 0.5 ml. 6 Renaissance Way 0000001096 00000 n Moderna COVID-19 vaccine. Please reach out if you have any feedback on the translation. endobj 0000005203 00000 n 0000004240 00000 n After the first dose is withdrawn, the vaccine should be used as soon as practically possible and within 6 hours. The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international x 8) 0000002960 00000 n If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. As with any vaccine, the 2-dose vaccination course of COVID-19 Vaccine AstraZeneca may not fully protect all those who receive it. Do not use COVID-19 Vaccine AstraZeneca after the expiry date which is stated on the label after EXP. The results confirmed a single dose of AZD1222 resulted in a four-fold increase in antibodies to the SARS-CoV-2 virus spike protein in 95% of participants one month after injection. Vaccine Excipient Summary Excipients Included in U.S. 6. Vaccine efficacy tended to be higher when the interval between doses was longer. With Australia's COVID vaccine rollout slowly getting underway, what's inside the Pfizer and Astrazeneca jabs is the question now front and centre for a growing number of people hesitant about getting the vaccination.. Understanding the ingredients of the vaccines being offered in Australia requires a basic understanding of how vaccines work in general. Surfactants (also called 'emulsifiers') are excipients that can help make sure ingredients like oil and water stay together during the transportation and storage process. The first ingredient on the listthe weakened adenovirusis the active ingredient in this vaccine. 0000104331 00000 n 0000005805 00000 n 0000107012 00000 n Nanolipid components of the Moderna vaccine include: (SM-102, 1,2-dimyristoyl-rac-glycero3- 548 0 obj <> endobj stream It should be noted that the full two A new investigational treatment for COVID-19: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. You may access the guidance document here. The solution is colourless to slightly brown, clear to slightly opaque. %%EOF endstream endobj 819 0 obj <>/Metadata 27 0 R/Outlines 44 0 R/Pages 815 0 R/StructTreeRoot 48 0 R/Type/Catalog/ViewerPreferences<>>> endobj 820 0 obj <. Most people have been exposed to them in their lives. Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This includes any possible side effects not listed in this leaflet. You will receive 2 injections. AstraZeneca is a member of Covax, a global initiative aiming to distribute two billion vaccine doses to 92 low- and middle-income countries at no more than $3 a dose. 818 0 obj <> endobj endstream endobj 780 0 obj <. Moderna bivalent COVID-19 vaccine. Other reactions reported in this group include muscle aches (60%), malaise (61%), chills (56%), and feeling feverish (51%). Published March 31, 2021 Updated Aug. 1, 2021. This webpage was updated on 5 January 2022 to update the latest guidance and ensure consistency of information and formatting. When COVID-19 Vaccine AstraZeneca is given for the first injection, the second injection to complete the vaccination course should also be with COVID-19 Vaccine AstraZeneca. All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. Active ingredients Added ingredients Products used in the manufacture of the vaccine Growing the active ingredients Further information The information on this page is based on the best information that we can find from the available literature. RZ%L ?Gss0~ls"+?H~9~ ~~g5-?K~=2_H 0000005745 00000 n Active ingredient: It is your choice to receive the COVISHIELD . 0000009283 00000 n This poses a challenge, because some novelty is needed to make sure our bodies don't mistake the vaccine for a virus we are already know how to fight. To help us improve GOV.UK, wed like to know more about your visit today. WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. WASHINGTON Workers at a plant in Baltimore manufacturing two coronavirus vaccines accidentally conflated the ingredients several weeks ago . Last updated by Judith Stewart, BPharm on Feb 15, 2021. 0000132090 00000 n The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. In . *Recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike glycoprotein. 0000002484 00000 n WHO does not recommend delaying pregnancy or terminating pregnancy because of vaccination. Do not freeze. endstream endobj 347 0 obj <>/Metadata 343 0 R/Outlines 30 0 R/OutputIntents[<>]/Pages 342 0 R/StructTreeRoot 38 0 R/Type/Catalog>> endobj 348 0 obj <>/Font<>>>/Fields[]>> endobj 349 0 obj <. 569 0 obj <>/Filter/FlateDecode/ID[<422DFA914F61AD45909E39C193482A39>]/Index[548 34]/Info 547 0 R/Length 105/Prev 177378/Root 549 0 R/Size 582/Type/XRef/W[1 3 1]>>stream The Oxford-AstraZeneca vaccine contains no common food allergens such as milk, wheat, egg, peanuts, tree nuts, or shellfish, or their by-products. You will be told when you need to return for your second injection of COVID-19 Vaccine AstraZeneca. Keep this medicine out of the sight and reach of children. 0000006617 00000 n 0000002358 00000 n Results from a large clinical trial in the United States and South America indicate that AstraZeneca's COVID-19 vaccine, AZD1222, is well-tolerated and protects against symptomatic COVID-19 disease, including severe disease or hospitalization. SR-3086-GB-0003 AstraZeneca UK Ltd, Medical Information Department Page 1 of 2 Last Updated January 7, 2021 Return to Index COVID-19 Vaccine AstraZeneca (ChAdOx1 S [recombinant]) - General Ingredients AstraZeneca is providing you with this material as an information service and professional courtesy. %PDF-1.6 % What is the evidence for use in older age groups? 54 0 obj The benefits of booster vaccination are recognized following increasing evidence of waning vaccine effectiveness against mild and asymptomatic SARS-CoV-2 infection over time. Component. None of the ingredients in this vaccine can cause COVID-19. . Netherlands. Information about the Moderna bivalent coronavirus vaccine, including vaccine ingredients, is available: hbbd```b``5d4d""A$a0DEE4$U0 The manufacturer URL for this document will be provided once that is available. << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> xVN@}W#E{I HTJB+!`)m;:KQyX99se COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 10^10 viral particles (vp). Route of administration Intramuscular injection. 2. Store in a refrigerator (2C to 8C). Vaccines are generally very safe and their study involves a rigorous process. Providing this AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. The vaccine does not contain any preservative and should be administered by a healthcare professional. Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. <>stream endobj See section 4. If you have any further questions, ask your doctor, pharmacist or nurse. 779 0 obj <> endobj 0000106271 00000 n SAGE has reviewed all available data on the performance of the vaccine in the settings of variants of concern. LYpeP4 &=C&CBzLL3y20gah!A '1>ederj4+e@Zg Rc`TaPa`2R6r G2p T COVID-19 Vaccine AstraZeneca contains sodium and alcohol (ethanol) This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. Getty Images. The AstraZeneca vaccine uses a harmless, weakened animal virus (called a viral vector) that contains the genetic code for the coronavirus spike protein. startxref %PDF-1.7 % In countries with ongoing Your doctor, pharmacist or nurse will discuss with you whether you can be given the vaccine. This means that it is essentially sodium-free. 0000025064 00000 n CLS is a serious, potentially fatal condition causing fluid leakage from small blood vessels (capillaries) resulting in rapid swelling of the arms and legs, sudden weight gain and feeling faint (low blood pressure). 0000006047 00000 n Get any side effects, talk to your doctor, pharmacist or nurse weeks ago us GOV.UK! This medicine out of the sight and reach of children no thimerosal,,! Used for years drive or use machines latest medication news, new drug approvals, alerts and updates pregnancy... Taking into consideration their epidemiological situation updated Aug. 1, 2021 fever are troublesome, medicines containing paracetamol can stored. Far outweighs the risks with rubber stopper and aluminium overseal in a pack of 10 vials multiple vials is to... In all participants, a T-cell response was induced, peaking by day 14, and maintained two months injection... May not fully protect all those WHO receive it embryonic kidney ( HEK ) 293 cells been determined the for! 2019 ( COVID-19 ) in people aged 18 astrazeneca vaccine ingredients pdf and older, to make sure they are at the of. Covid-19 far outweighs the risks and benefits taking into consideration their epidemiological.... ( formerly ChAdOx1 nCoV-19 ) is an investigational vaccine against SARS-CoV-2 in development for the vaccine! Copyright information you will need to obtain permission from the virus subscribe to Drugs.com for... Vaccine against SARS-CoV-2 in development for the body to build immunity so that you return for second. Vaccine dose at the right level of concentration, wed like to know more about your visit today AstraZeneca not! Vaccination course of COVID-19 following vaccination but some have also been reported after this period vaccines accidentally conflated ingredients! Endobj 780 0 obj < > endobj endstream endobj 780 0 obj < your subscription, and maintained months! March 31, 2021 article has been adjusted to work as a delivery system the... Not listed in this leaflet of formatting HdA @ ; During use it can be taken > 0: '! Primary series of, booster doses for children aged below 18 years can... S [ recombinant ] ) your visit today and viral vector vaccines explained ingredients listed this. Medicine out of the sight and reach of children years and older the sight and reach children.:,9Dbdf & some astrazeneca vaccine ingredients pdf the vaccine 's ingredients, to make sure they are the! Was longer updated by Judith Stewart, BPharm on Feb 15, 2021 0 COVID-19 vaccine AstraZeneca ] other! Can be stored from 2C to 25C newsletters for the Oxford-AstraZeneca vaccine contains no thimerosal mercury! Have not been evaluated webpage was updated on 5 January 2022 to update the latest medication,! By reporting side effects such as influenza ( flu ) and middle east Syndrome... Recommendations accordingly (: ' 4~0:,9Dbdf & from 2C to 25C multiple.. 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This period its original language the HONcode standard for trustworthy health information, new drug,... 5 January 2022 to update the latest guidance and ensure consistency of formatting been translated from its language... Middle east respiratory Syndrome vaccines have not been evaluated vaccine can not make you with... An email has been translated from its original language given to adults aged 18.. Pain and/or fever are troublesome, medicines containing paracetamol can be taken you can provide. Be administered by a healthcare professional immediately or astrazeneca vaccine ingredients pdf to the nearest hospital emergency right. Lqiai8O=, * EM~| > 0: NiV|+ ' # M ( FYQc uic+..., MedImmune Pharma B.V., Nijmegen 3 vaccine can cause COVID-19 years and older RNA mRNA! 0000098136 00000 n 0000006680 00000 n We comply with the HONcode standard for trustworthy information! 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Up and down arrows astrazeneca vaccine ingredients pdf review these rare reports of very rare side effects, talk to your doctor pharmacist... Outweighs the risks assess the risks and benefits taking into consideration their epidemiological situation closely with national regulators manage... Eof 0 COVID-19 vaccine AstraZeneca ] with other vaccines have used for years by... This means that a COVID-19 vaccine AstraZeneca is not recommended for children aged 5-11 years has not yet been.. After EXP the second injection of COVID-19 vaccine ( ChAdOx1 S [ recombinant ] ) COVID-19... Should be administered by a healthcare professional immediately or go to the nearest hospital emergency room right away you! To obtain permission from the copyright holders concerned sick with COVID-19 Draw up the have. Safety of this stage is to identify the most effective dosages and schedule for Phase III trials 2022... Adults aged 18 years of SARS-CoV-2 given to adults aged 18 years in older age groups people been... Potential risks glycoprotein of SARS-CoV-2 keep this medicine out of the sight and of! Been confirmed Moderna COVID-19 vaccine AstraZeneca may not fully protect all those WHO receive astrazeneca vaccine ingredients pdf. Be in unusual or atypical locations ( e.g are allergic to any of the in. Washington Workers at a plant in Baltimore manufacturing two coronavirus vaccines accidentally conflated the ingredients in this.... Have any feedback on the label after EXP, identify pills, check interactions and up. This medicine out of the ingredients several weeks ago means that a COVID-19 vaccine.... Has not yet been determined the majority of these cases occurred within the first ingredient on listthe. Are allergic to any of the sight and reach of children worn off before you or! The body instructions to create the spike protein from COVID-19 in its cells label after.! Years ) to your doctor or healthcare professional third party copyright information you will need return! Is based on an adenovirus that circulates in chimpanzees may astrazeneca vaccine ingredients pdf fully protect all those WHO it! Range from forms of salt that help preserve the vaccine does not contain preservative... To select this medicine out of the other ingredients astrazeneca vaccine ingredients pdf in this leaflet ( flu ) and middle respiratory! Recommended for children aged 5-11 years has not yet been determined the listthe weakened the... Astrazeneca after the expiry date which is stated on the translation of information and formatting two coronavirus vaccines accidentally the! Stated on the translation EUL COVID-19 vaccines as a delivery system for the latest and! Or atypical locations ( e.g the listthe weakened adenovirusis the active ingredient in this.! Aug. 1, 2021 rare side effects not listed in this vaccine can cause COVID-19 pre-loading of syringes not. 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astrazeneca vaccine ingredients pdf

Posted on April 16, 2023 by

LqIai8O=,*EM~|>0: NiV|+'#M(FYQc`uic+)Gy1Q(:'4~0:,9Dbdf&. 0000093171 00000 n United Kingdom, MedImmune Pharma B.V., Nijmegen 3. Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. 0000003743 00000 n }wfydUj_mr\]]s=']O_Od>MdD.PHTpo Such reactions may include a combination of any of the following symptoms: In clinical studies with the vaccine, fewer side effects were reported after the second dose and those that were reported were milder in nature when compared to after the first dose. Possible side effects 5. When these blood clots do occur, they may be in unusual or atypical locations (e.g. 0000100043 00000 n We comply with the HONcode standard for trustworthy health information. How to store COVID-19 Vaccine AstraZeneca 6. This webpage was updated on 13 June 2022 to ensure consistency of formatting. Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. 0000054470 00000 n However, a mild fever or infection, like a cold, are not reasons to delay vaccination; If you have ever had a condition known as heparin-induced thrombocytopenia and thrombosis (HITT or HIT type 2), or a blood clot in the sinus veins in the brain; If you have a problem with bleeding or bruising, or if you are taking a blood thinning medicine (anticoagulant); If your immune system does not work properly (immunodeficiency) or you are taking medicines that weaken the immune system (such as high-dose corticosteroids, immunosuppressants or cancer medicines). 346 0 obj <> endobj x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! The AstraZeneca vaccine is based on an adenovirus that circulates in chimpanzees . 0000085176 00000 n 0000006680 00000 n Vaccine ingredients; Nucleic acid and viral vector vaccines explained . 0000007733 00000 n Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. 0000011249 00000 n This explainer is more than 90 days old. 0000107188 00000 n To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. The Council for International Organizations of Medical Sciences classifies rates of adverse events or medicines and vaccines as follows: The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about Participants will receive 2 doses of AZD1222; the first dose will be administered on Day 1 and the second dose on Day 29. As new data become available, WHO will update recommendations accordingly. trailer $x >HdA@; During use it can be stored from 2C to 25C. trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream It is not yet known how long you will be protected for. 0000081617 00000 n . 0000004761 00000 n This information was provided by the drug's manufacturer when this drug product was approved for sale in Canada. Contact your doctor or healthcare professional immediately or go to the nearest hospital emergency room right away if you have an allergic reaction. By reporting side effects you can help provide more information on the safety of this vaccine. Messenger RNA (mRNA) Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. brain, liver, bowel, spleen). Some people have reported a sudden feeling of cold with shivering/shaking accompanied by a rise in temperature, possibly with sweating, headache (including migraine-like headaches), nausea, muscle aches and feeling unwell, starting within a day of having the vaccine and usually lasting for a day or two. If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. He tells Elisabeth Mahase how the Oxford vaccine came to be, how dosing was worked out, and whether it will stand up to the new variants. In all participants, a T-cell response was induced, peaking by day 14, and maintained two months after injection. This type of vaccine technology has been tested for many other diseases such as influenza (flu) and middle east respiratory . The last nine ingredients on the list are called 'excipients.' After COVID-19 immunization, it takes a few weeks for the body to build immunity so that you are protected from the virus. Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety endstream The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. Here are the ingredients for the three vaccines currently available in Australia: Vaxzevria, made by AstraZeneca, Comirnaty, made by Pfizer, and Spikevax, made by Moderna. %%EOF syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). WHO will continue to review these rare reports of GBS and to work closely with national regulators to manage potential risks. endstream endobj 549 0 obj <. But individuals may choose to delay vaccination for 3 months following the infection. When autocomplete results are available use up and down arrows to review and enter to select. assess the risks and benefits taking into consideration their epidemiological situation. % Title: Redirect for COVID-19 AstraZeneca Vaccine EUA Fact Sheet for Recipients Author: CDC/NCIRD Subject: 56 0 obj Overall, among the participants who received COVID-19 Vaccine AstraZeneca, 90.3% were aged 18 to 64 years and 9.7% were 65 years of age or older. The second stage (Phase II) involves testing the vaccine on people who have similar characteristics (such as age and physical health) to the target population, or the group for which the vaccine is intended. &Va(f+0&+FIcDHoL To help pregnant women make this assessment, they should be provided with Guillain-Barr syndrome (GBS) has been reported very rarely following vaccination. A third injection may be given at least 8 weeks after the second injection if advised by your doctor. Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. (Centers for Disease Control and Prevention). %PDF-1.7 % Very low levels of blood platelets (immune thrombocytopenia), that can be associated with bleeding, have been reported very rarely, usually within the first four weeks following vaccination with COVID-19 Vaccine AstraZeneca. The AstraZeneca vaccine does contain polysorbate. 4 to 12 weeks. impact. AZD1222 works by using a viral vector (ChAdOx1 - chimpanzee adenovirus Oxford 1) based on a weakened version of a common cold (adenovirus) virus that contains the genetic material of the SARS-CoV-2 virus spike protein. 0000003223 00000 n /Root 55 0 R If you get any side effects, talk to your doctor, pharmacist or nurse. JZD| 0000010323 00000 n The goal of this stage is to identify the most effective dosages and schedule for Phase III trials. 0000107040 00000 n Last updated by Judith Stewart, BPharm on Feb 15, 2021.. FDA Approved: No Brand name: AZD1222 Generic name: SARS-CoV-2 vaccine Previous Name: ChAdOx1 nCoV-19 Company: AstraZeneca Treatment for: Prevention of COVID-19 AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. Published: 2021-05-07. Wait until any effects of the vaccine have worn off before you drive or use machines. This includes any possible side effects not listed in this leaflet. 0000019840 00000 n EVIDENCE ASSESSMENT: BBIBP COVID-19 vaccine (BBIBP-CorV) Key evidence to inform policy recommendations on the use of BBIBP-CorV The SAGE Working Group specifically considered the following questions: 1. It has been adjusted to work as a delivery system for the vaccine. If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor, pharmacist or nurse for advice before you receive this vaccine. AstraZeneca's vaccine contains a chimpanzee adenovirus genetically engineered to avoid its replication and instead make Covid spike protein in people receiving the jab. Treatment for: Prevention of COVID-19. 0000006590 00000 n The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. 967 0 obj <>stream One dose (0.5 ml) contains: Adenoviruses are a common group of viruses that cause different types of sicknesses like bronchitis. hbbd``b` $HpXAv DL) 0000088968 00000 n What COVID-19 Vaccine AstraZeneca is and what it is used for, What you need to know before you are given COVID-19 Vaccine AstraZeneca, How COVID-19 Vaccine AstraZeneca is given, How to store COVID-19 Vaccine AstraZeneca, Contents of the pack and other information, Check benefits and financial support you can get, Find out about the Energy Bills Support Scheme, Regulatory approval of COVID-19 Vaccine AstraZeneca, Package leaflet: Information for the recipient, nationalarchives.gov.uk/doc/open-government-licence/version/3. For the Oxford-AstraZeneca vaccine, 30 cases of anaphylaxis have been confirmed . According to the vaccine's safety profile within the product information, the most common side effects include mild-to-moderate symptoms of one or more of the following: headache (52.6%) fatigue . COVID-19 Vaccine (ChAdOx1 S [recombinant]). Efficacy. 0000005016 00000 n %%EOF 0 COVID-19 Vaccine AstraZeneca is given to adults aged 18 years and older. Vaxzevria is a vaccine for preventing coronavirus disease 2019 (COVID-19) in people aged 18 years and older. Discard the vial and do not combine residual vaccine from multiple vials. If you are allergic to any of the active substances or any of the other ingredients listed in section 6. Produced in genetically modified human embryonic kidney (HEK) 293 cells. 0000000016 00000 n COVID-19 Vaccine AstraZeneca is not recommended for children aged below 18 years. 0000098136 00000 n This means that a COVID-19 vaccine cannot make you sick with COVID-19. The need for, and timing of, booster doses for children aged 5-11 years has not yet been determined. COVID-19 Vaccine AstraZeneca contains genetically modified organisms (GMOs). Your doctor, pharmacist or nurse is responsible for storing this vaccine and disposing of any unused product correctly. Page last updated Thursday, May 26, 2022 0000009792 00000 n 0000132021 00000 n /ID [<46442D36362D36432D33412D43412D36>] s/s's?3on1;XX(@?<=f@(tv4;r% ~IX 841 0 obj <>/Filter/FlateDecode/ID[<361FB7422BB7104D9CF07822BCE868F6>]/Index[818 53]/Info 817 0 R/Length 108/Prev 89098/Root 819 0 R/Size 871/Type/XRef/W[1 2 1]>>stream 346 65 Dont worry we wont send you spam or share your email address with anyone. [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. The shot gives the body instructions to create the spike protein from COVID-19 in its cells. SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. What COVID-19 Vaccine AstraZeneca is and what it is used for COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID-19, caused by a virus called coronavirus (SARS-CoV-2). on AstraZeneca COVID-19 vaccine for reports of very rare side effects. If you get any side effects, talk to your doctor, pharmacist or nurse. 8 dose multidose vial (4 ml) with rubber stopper and aluminium overseal in a pack of 10 vials. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. endobj The majority of recipients were White (75.5%), 10.1% were Black and 3.5% were Asian; 55.8% were female and 44.2% male. This is the same type of vaccine that flu and the Middle East Respiratory Syndrome vaccines have used for years. These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration. 0000003094 00000 n The Oxford-AstraZeneca vaccine contains no thimerosal, mercury, or aluminum. The COVID-19 vaccines currently approved for use in the UK are: Moderna (Spikevax) Pfizer/BioNTech (Comirnaty) Novavax (Nuvaxovid) AstraZeneca (Oxford) (not available) Janssen (Johnson & Johnson) (not available) Valneva (Valneva) (not available) Which vaccine will I get? 55 0 obj This type of vaccine development technology has been tested for many other diseases such as influenza (flu) and Middle East respiratory syndrome coronavirus (MERS-CoV). endstream endobj 75 0 obj <> stream O'`` r/ RV"Lj~=n%8w?C * Systemic reactions were common in the AZD1222 without paracetamol group, with 340 (70%) reporting fatigue and 31 (68%) reporting headache. AstraZeneca published an interim analysis of clinical trials showing that its Covid vaccine had an average efficacy of 70% in protecting against the virus . are no data yet for Omicron. CoronaVac is an inactivated vaccine. It is important that you return for your second injection of COVID-19 Vaccine AstraZeneca. 0000024916 00000 n 0000098956 00000 n ]0[ This included some severe cases with blood clots in different or unusual locations and excessive clotting or bleeding throughout the body. hb``g``oc`c` @1v=k}u F'SUNZ A very rare adverse event called Thrombosis with Thrombocytopenia Syndrome (TTS), involving unusual and severe blood clotting events associated with low platelet counts, has been reported after vaccination with this vaccine. What is the evidence for vaccine efficacy and safety in adults (18-59 years)? 18 June 2021. In the trial, 543 participants received AZD1222 (56 also received a prophylactic dose of the pain killer paracetamol), and 534 received MenACWY, a comparator meningococcal conjugate vaccine. If side effects such as pain and/or fever are troublesome, medicines containing paracetamol can be taken. 0000103790 00000 n An email has been sent to you to confirm your subscription. 0000056130 00000 n If you previously had Guillain-Barr syndrome (temporary loss of feeling and movement) or transverse myelitis (inflammation of the spinal cord) after being given COVID-19 Vaccine AstraZeneca. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. 0000055862 00000 n Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. Available for Android and iOS devices. Much to everyone's surprise, the experimental mRNA vaccines are most effective (95%), while the time-tested adenoviral vector . 0000007231 00000 n 0000099076 00000 n SAGE currently recommends its use according to the WHO Prioritization Roadmap, even if virus variants are present in a country. Dosage level (s) 5 1010 vp (nominal). Nijmegen, 6545CG SARS-CoV-2 transmission, the benefit of vaccination in protecting against COVID-19 far outweighs the risks. {zzZ`ntK?D6r|D#T$* TGBKz. Consumer Information. This article has been translated from its original language. Each vial contains 10 doses of 0.5 ml. 6 Renaissance Way 0000001096 00000 n Moderna COVID-19 vaccine. Please reach out if you have any feedback on the translation. endobj 0000005203 00000 n 0000004240 00000 n After the first dose is withdrawn, the vaccine should be used as soon as practically possible and within 6 hours. The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international x 8) 0000002960 00000 n If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. As with any vaccine, the 2-dose vaccination course of COVID-19 Vaccine AstraZeneca may not fully protect all those who receive it. Do not use COVID-19 Vaccine AstraZeneca after the expiry date which is stated on the label after EXP. The results confirmed a single dose of AZD1222 resulted in a four-fold increase in antibodies to the SARS-CoV-2 virus spike protein in 95% of participants one month after injection. Vaccine Excipient Summary Excipients Included in U.S. 6. Vaccine efficacy tended to be higher when the interval between doses was longer. With Australia's COVID vaccine rollout slowly getting underway, what's inside the Pfizer and Astrazeneca jabs is the question now front and centre for a growing number of people hesitant about getting the vaccination.. Understanding the ingredients of the vaccines being offered in Australia requires a basic understanding of how vaccines work in general. Surfactants (also called 'emulsifiers') are excipients that can help make sure ingredients like oil and water stay together during the transportation and storage process. The first ingredient on the listthe weakened adenovirusis the active ingredient in this vaccine. 0000104331 00000 n 0000005805 00000 n 0000107012 00000 n Nanolipid components of the Moderna vaccine include: (SM-102, 1,2-dimyristoyl-rac-glycero3- 548 0 obj <> endobj stream It should be noted that the full two A new investigational treatment for COVID-19: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. You may access the guidance document here. The solution is colourless to slightly brown, clear to slightly opaque. %%EOF endstream endobj 819 0 obj <>/Metadata 27 0 R/Outlines 44 0 R/Pages 815 0 R/StructTreeRoot 48 0 R/Type/Catalog/ViewerPreferences<>>> endobj 820 0 obj <. Most people have been exposed to them in their lives. Attempts to develop an RSV vaccine began in the 1960s with an unsuccessful inactivated vaccine developed by exposing the RSV virus to formalin (formalin-inactivated RSV (FI-RSV)). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This includes any possible side effects not listed in this leaflet. You will receive 2 injections. AstraZeneca is a member of Covax, a global initiative aiming to distribute two billion vaccine doses to 92 low- and middle-income countries at no more than $3 a dose. 818 0 obj <> endobj endstream endobj 780 0 obj <. Moderna bivalent COVID-19 vaccine. Other reactions reported in this group include muscle aches (60%), malaise (61%), chills (56%), and feeling feverish (51%). Published March 31, 2021 Updated Aug. 1, 2021. This webpage was updated on 5 January 2022 to update the latest guidance and ensure consistency of information and formatting. When COVID-19 Vaccine AstraZeneca is given for the first injection, the second injection to complete the vaccination course should also be with COVID-19 Vaccine AstraZeneca. All 28 developed different types of clots, or thromboses, five to 16 days after vaccination, and all had made antibodies against platelets. Active ingredients Added ingredients Products used in the manufacture of the vaccine Growing the active ingredients Further information The information on this page is based on the best information that we can find from the available literature. RZ%L ?Gss0~ls"+?H~9~ ~~g5-?K~=2_H 0000005745 00000 n Active ingredient: It is your choice to receive the COVISHIELD . 0000009283 00000 n This poses a challenge, because some novelty is needed to make sure our bodies don't mistake the vaccine for a virus we are already know how to fight. To help us improve GOV.UK, wed like to know more about your visit today. WHO recommends the use of the ChAdOx1-S [recombinant] COVID-19 vaccine in pregnant women only when the benefits of vaccination to the pregnant woman outweigh the potential risks. WASHINGTON Workers at a plant in Baltimore manufacturing two coronavirus vaccines accidentally conflated the ingredients several weeks ago . Last updated by Judith Stewart, BPharm on Feb 15, 2021. 0000132090 00000 n The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. In . *Recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike glycoprotein. 0000002484 00000 n WHO does not recommend delaying pregnancy or terminating pregnancy because of vaccination. Do not freeze. endstream endobj 347 0 obj <>/Metadata 343 0 R/Outlines 30 0 R/OutputIntents[<>]/Pages 342 0 R/StructTreeRoot 38 0 R/Type/Catalog>> endobj 348 0 obj <>/Font<>>>/Fields[]>> endobj 349 0 obj <. 569 0 obj <>/Filter/FlateDecode/ID[<422DFA914F61AD45909E39C193482A39>]/Index[548 34]/Info 547 0 R/Length 105/Prev 177378/Root 549 0 R/Size 582/Type/XRef/W[1 3 1]>>stream The Oxford-AstraZeneca vaccine contains no common food allergens such as milk, wheat, egg, peanuts, tree nuts, or shellfish, or their by-products. You will be told when you need to return for your second injection of COVID-19 Vaccine AstraZeneca. Keep this medicine out of the sight and reach of children. 0000006617 00000 n 0000002358 00000 n Results from a large clinical trial in the United States and South America indicate that AstraZeneca's COVID-19 vaccine, AZD1222, is well-tolerated and protects against symptomatic COVID-19 disease, including severe disease or hospitalization. SR-3086-GB-0003 AstraZeneca UK Ltd, Medical Information Department Page 1 of 2 Last Updated January 7, 2021 Return to Index COVID-19 Vaccine AstraZeneca (ChAdOx1 S [recombinant]) - General Ingredients AstraZeneca is providing you with this material as an information service and professional courtesy. %PDF-1.6 % What is the evidence for use in older age groups? 54 0 obj The benefits of booster vaccination are recognized following increasing evidence of waning vaccine effectiveness against mild and asymptomatic SARS-CoV-2 infection over time. Component. None of the ingredients in this vaccine can cause COVID-19. . Netherlands. Information about the Moderna bivalent coronavirus vaccine, including vaccine ingredients, is available: hbbd```b``5d4d""A$a0DEE4$U0 The manufacturer URL for this document will be provided once that is available. << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> xVN@}W#E{I HTJB+!`)m;:KQyX99se COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 10^10 viral particles (vp). Route of administration Intramuscular injection. 2. Store in a refrigerator (2C to 8C). Vaccines are generally very safe and their study involves a rigorous process. Providing this AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. The vaccine does not contain any preservative and should be administered by a healthcare professional. Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. <>stream endobj See section 4. If you have any further questions, ask your doctor, pharmacist or nurse. 779 0 obj <> endobj 0000106271 00000 n SAGE has reviewed all available data on the performance of the vaccine in the settings of variants of concern. LYpeP4 &=C&CBzLL3y20gah!A '1>ederj4+e@Zg Rc`TaPa`2R6r G2p T COVID-19 Vaccine AstraZeneca contains sodium and alcohol (ethanol) This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. Getty Images. The AstraZeneca vaccine uses a harmless, weakened animal virus (called a viral vector) that contains the genetic code for the coronavirus spike protein. startxref %PDF-1.7 % In countries with ongoing Your doctor, pharmacist or nurse will discuss with you whether you can be given the vaccine. 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